Validating Orchid’s Celiac Disease Genetic Risk Score

Written by Orchid Bioinformatics Staff

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Orchid's clinical reports include a genetic risk score (GRS) for celiac disease, which has been validated on data from the UK Biobank. We present our findings from this validation study in the following white paper. We found that the GRS performed well, particularly for identifying individuals with elevated risk of the disease relative to the population. The celiac disease GRS is currently only available to individuals of European ancestry, due to concerns about loss of accuracy in other ancestry groups, although research efforts are underway to address this issue.

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